None of the EOAD patients had a family history suggestive of autosomal dominant disease, although a few had one or two affected relations.
Research on the topic has focused on clinical, neuropsychological, and functional and structural imaging features.
A higher prevalence of language impairment or other neocortical functions Functional imaging with single photon emission computed tomography (SPECT) and positron emission tomography (PET) has more consistently reported more severe perfusional and metabolic deficits in the temporoparietal areas in EOAD, The few structural imaging studies published to date have shown greater grey matter atrophy in EOAD.
Objective: To examine the brain structural correlates of age at onset in patients with Alzheimer’s disease.
Methods: We studied nine patients with early onset (age ⩽65 years), nine with late onset (age 65, n = 17) subjects.
Results: The patients with EOAD showed greater neocortical atrophy at the temporoparietal junction while the patients with LOAD showed greater hippocampal atrophy.
The results could not be accounted for by the apolipoprotein E genotype.
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The patients were closely matched for clinical severity: 3/2/3/1 patients had clinical dementia rating of 0.5/1/2/3, respectively, in both the groups.